Perspective: Lyme disease patients’ mental and physical health in a COVID-19 pandemic

A broad range of factors associated with mental health problems in COVID-19 that have been seen in individuals with Lyme disease were identified in an epidemiologic review. “Age, gender, marital status, education, occupation, income, place of living, close contact with people with COVID-19, comorbid physical and mental health problems, exposure to COVID-19 related news and social media, coping styles, stigma, psychosocial support, health communication, confidence in health services, personal protective measures, risk of contracting COVID-19, and perceived likelihood of survival,” writes Hossain and colleagues. [1]

Lyme disease mental health

A broad range of mental health issues has been described in Lyme disease. In a 1990 report, Logigian and colleagues from Tufts University School of Medicine, in Boston, describe rage in patients with chronic neurologic Lyme disease. “Eight patients had excessive daytime sleepiness, and seven had extreme irritability. They became angry over circumstances that previously caused only minor annoyance.” [2]

Dr. Fallon and colleagues from the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, in New York, have described a wide range of neuropsychiatric complications associated with Lyme disease. The authors described Lyme disease patients exhibiting “paranoia, dementia, schizophrenia, bipolar disorder, panic attacks, major depression, anorexia nervosa, and obsessive-compulsive disorder.” [3]

Dr. Bransfield from Rutgers-Robert Woods Johnson Medical School, Department of Psychiatry, also shared his understanding of the role in which Lyme disease may cause mental health symptoms. “LB [Lyme borreliosis] causes immune and metabolic effects that result in a gradually developing spectrum of neuropsychiatric symptoms, usually presenting with significant comorbidity which may include developmental disorders, autism spectrum disorders, schizoaffective disorders, bipolar disorder, depression, anxiety disorders (panic disorder, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, intrusive symptoms), eating disorders, decreased libido, sleep disorders, addiction, opioid addiction, cognitive impairments, dementia, seizure disorders, suicide, violence, anhedonia, depersonalization, dissociative episodes, derealization, and other impairments,” writes Bransfield. [4]

Lyme disease physical health

The list of health conditions associated with Lyme disease continues to grow. The list now includes:

1. Lyme encephalopathy [2.5]
2. Lyme neuropathy [6]
3. Lyme carditis [7]
4. Autonomic dysfunction – Positional Orthostatic Tachycardic Syndrome (POTS) [8]
5. Post-treatment Lyme fatigue – Post-Lyme disease [9]
6. Neuropathic pain [10]
7. Persistent symptoms after Lyme disease [11]
8. Lyme disease with co-infection (e.g., Babesia) [12]

Perspective

The mental and physical health of Lyme disease patients described by these authors is not fully understood. Nevertheless, we need to address these concerns, as Lyme disease patients are genuinely concerned about the COVID-19 pandemic. Clinicians should be aware that Lyme disease patients frequently exhibit mental health symptoms similar to those present with COVID-19. And should therefore not immediately dismiss Lyme disease for COVID-19.