Rifampin for Lyme Disease: When Doxycycline Isn’t Enough

When I first began treating Lyme disease in 1987, the primary antibiotic prescribed was doxycycline. This choice was driven by doxycycline’s effectiveness not only against Lyme disease itself but also against co-infections such as Ehrlichia and Anaplasmosis.

These co-infections, often transmitted by the same ticks that carry Lyme, present additional challenges in patient management.

However, when patients couldn’t tolerate doxycycline due to side effects or failed to respond to the treatment, rifampin emerged as a viable alternative.

Ultimately, Lyme disease treatment is highly individualized. Each patient responds differently to various treatment protocols, and decisions must be guided by the specific infections involved and the patient’s clinical presentation.

The evolution of treatment options reflects the ongoing commitment to providing the most effective care possible, tailored to the unique needs of each patient.

As we continue to learn more about Lyme disease and its co-infections, it is essential to stay informed and adaptable, ensuring that patients receive the best care based on the latest evidence.